College football odds, picks, predictions for Week 1, 2026: Computer backing Auburn, Cincinnati

While the 2026 college football season got a hearty appetizer with Week 0, the main course will be served with the Week 1 college football schedule. There are 90 games involving FBS teams on the slate, with several intriguing non-conference matchups. Lane Kiffin makes his LSU debut versus Clemson on Saturday, which has the Tigers of Baton Rouge as 10-point home favorites per the latest Week 1 college football odds. Then on Sunday, the only ranked contest of the weekend occurs with Kiffin's former squad in No. 9 Ole Miss vs. No. 24 Louisville (+7). Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here:

Other top non-conference games include UCLA vs. Cal (+1.5), which used to be a Pac-12 rivalry, as well as Baylor vs. Auburn (-7.5) at a neutral site in Atlanta. The No. 1 team in the land, Ohio State, is at -50.5 to target with Week 1 college football picks as the Buckeyes begin their campaign hosting Ball State. Before locking in any Week 1 college football picks, be sure to see the latest college football predictions from SportsLine's proven model.

The model simulates every…

Original source: https://www.cbssports.com/