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Even those not on the West Coast could have a little more interest in making Week 2 NFL picks on either the Rams or 49ers. How those teams respond after playing in Australia last week is something that will be highly observed. Both are fortunate to have home games on the Week 2 NFL schedule, with San Fran hosting Miami on Sunday, and L.A. hosting the Giants on Monday. The Niners are 12.5-point favorites for their contest, which is the biggest NFL spread of the young season. Claim the latest Polymarket promo code CBSSPORTS to get a $50 bonus after $10 in trades:

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The Week 2 NFL odds also have the Rams as heavy favorites, as they're giving 7 points to the Giants, with Big Blue getting back-to-back primetime appointments. This pair of matchups are among the six games with a line of at least a touchdown, as the opening week clearly influenced the oddsmakers. All of the updated Week 2 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 2 NFL picks now.

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The model, which simulates every NFL game 10,000 times…

Original source: https://www.cbssports.com/

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