NFL Week 2 game picks: Odds and expert predictions for every matchup

The 2026 NFL regular season began with an array of exciting games and eye-opening results, and Week 2 provides another chance for the contenders and pretenders to separate themselves.

The marquee matchup arrives early with the first "Thursday Night Football" game of the year. The Buffalo Bills open new Highmark Stadium by hosting the Detroit Lions in a showdown of explosive offenses. But the Week 2 slate is also littered with games featuring teams looking to get off to a 2-0 start or avoid an 0-2 start.

Though the Chicago Bears and Houston Texans each qualified for the postseason last year after losing their first two games, only 35 of 288 teams since 1990 had recovered from an 0-2 start to make the playoffs prior to the 2025 season, according to the NFL.

Here's a look at the early expert picks, predictions and odds for every game during Week 2 of the 2026 NFL season:

Odds courtesy of BetMGM as of Tuesday, Sept. 15 at 12:30 p.m. ET.

"The last time these two teams played came in 2024 in a game the Bills ended up winning 48-42. We got 90 total points. We might top that here. The Over/Under should…

Original source: https://www.usatoday.com/sports/